Anxiety and Depression: Two Sides of the Same Coin?

– Posted in: Anxiety

Modern psychiatry has long held that Anxiety Disorder and depression are two distinct conditions. 

However, in the real world, many suffer from both. Surveys show that half of Anxiety Disorder sufferers also have symptoms of clinical depression. And 60-70 percent of people with major depression also have an Anxiety Disorder. 

Evidence is growing that they are really two aspects of one disorder. Looking at them that way, some experts say, could speed the development of therapy and medications that better treat both conditions.

David Barlow, director of the Center for Anxiety and Related Disorders at Boston University, states that:

[Anxiety Disorders and depression are] probably two sides of the same coin. The genetics seem to be the same; the neurobiology seems to overlap.

This post explores several similarities between Anxiety Disorders and depression, along with the risks of getting both disorders, the benefits of early treatment, and a summary of how the disorders are treated together.

Common reactions of people with both Anxiety Disorders and depression

Life stressors: Anxiety and depression reactions

Anxiety Disorders and depression feed on each other, each making the other worse. David Barlow says that, “Some people with the vulnerability react with anxiety to life stressors and some, in addition, go beyond that to become depressed.” He adds,

Depression seems to be a shutdown. Anxiety is a kind of looking to the future, seeing dangerous things that might happen in the next hour, day or weeks. Depression is all that with the addition of “I really don’t think I’m going to be able to cope with this, maybe I’ll just give up.” It’s shutdown marked by mental, cognitive or behavioral slowing.”

In groundbreaking research, Kenneth S. Kendler, a behavioral geneticist from Virginia Commonwealth University in Richmond, offers a new way of looking at psychiatric conditions. He sees a small cluster of genetic risk factors creating “internalizing disorders” such as Anxiety Disorder and depression, which cause sufferers to be miserable. Another set of genetic factors finds expression in “externalizing disorders” such as substance abuse and antisocial behavior — conditions that make others around them miserable.

Avoidant coping style is shared between Anxiety Disorders and depression

Avoiding what you fear

Anxiety Disorders and depression share an avoidant coping style. Sufferers avoid what they fear instead of developing the skills to handle the kinds of situations that make them uncomfortable. 

Often, a lack of social skills is at the root of their avoidant behavior. Jerilyn Ross, LICSW, president of the Anxiety Disorders Association of America (ADDA), says,

[The link between Social Phobia and depression is] dramatic. It often affects young people who can’t go out, can’t date, don’t have friends. They’re very isolated, all alone, and feel cut off.

Evidence of shared genetic traits

Brain mechanisms gone awry

At the center of the double disorder are shared brain mechanisms gone awry. Studies have shown that the stress response system is overactive in patients with both Anxiety Disorders and depression, which sends the emotional centers of the brain — including the “fear center” in the amygdala — into hyperactivity. Secretions of the stress hormone cortisol, triggered by repeated trauma, reduce the activity of the gene that produces the 5-HT1A serotonin receptor, which is an important brain messenger implicated in both Anxiety Disorders and depression.

Another study from researchers at the National Institute of Mental Health has found that, in people with both Panic Disorder and depression, there is a significant decrease in a type of receptor (5-HT1A) for the neurotransmitter serotonin.

Early treatment of Anxiety Disorders can prevent depression

Early treatment prevents depression

Anxiety usually precedes depression developmentally, with Anxiety Disorders most commonly beginning in late childhood or adolescence and depression a few years later, in the mid-20s. Psychologist Michael Yapko of San Diego points out a flaw in thinking common in both disorders: 

The shared cornerstone of Anxiety and depression is the perceptual process of overestimating the risk in a situation and underestimating personal resources for coping.

Yapko sees a huge opportunity for the prevention of depression, as the average age of first onset is now mid-20s. He says,

A young person is not likely to outgrow anxiety unless treated and taught cognitive skills. But aggressive treatment of the anxiety when it appears can prevent the subsequent development of depression.

Who is at risk for combined Anxiety Disorder and depression? 

Risk: Heredity, age, environment

There’s definitely a family heredity component in the risk for developing Anxiety Disorder and depression together. Joseph Himle, Ph.D., Associate Director of the Anxiety Disorders Unit at the University of Michigan, says,

Looking at [what disorders populate] the family history of a person who presents with either primary Anxiety or depression provides a clue to whether he or she will end up with both.

The nature of the Anxiety Disorder also has an influence. Obsessive-Compulsive Disorder, Panic Disorder and Social Phobia are particularly associated with depression. Specific Phobias are less so.

Age plays a role, as well. Himle states, 

A person who develops an Anxiety Disorder for the first time after age 40 is likely also to have depression. Someone who develops panic attacks for the first time at age 50 often has a history of depression or is experiencing depression at the same time.

Sometimes a vulnerability to Anxiety Disorders are inherited by a person, and sometimes they are transmitted to children by parental overconcern. Yapko states that: 

The largest group of depression/Anxiety sufferers is Baby Boomers. The fastest growing group is their children. They can’t teach kids what they don’t know. Plus their desire to raise perfect children puts tremendous pressures on the kids. They’re creating a bumper crop of anxious/depressed children.

Treatment is similar for Anxiety Disorders and depression

Treatment of Anxiety Disorder and depression together

The treatments that work best for depression also combat Anxiety Disorder. Cognitive-Behavioral Therapy (CBT) is very successful in working with the response patterns central to both conditions. And the drugs most commonly used against depression, the SSRI’s, or selective serotonin reuptake inhibitors, have also been proved effective against an array of Anxiety Disorders, from Social Phobia to Panic Disorder and Post Traumatic Stress Disorder (PTSD). Which drug a patient should get is based more on what can be tolerated rather than on symptoms.

Treatment rarely centers on which disorder, the Anxiety Disorder or the depression, came first. “In many cases,” says Ross of the ADAA, “the depression exists because the anxiety is so draining. Once you treat the anxiety, the depression lifts.”

Treatment usually is targeted at depression and the Anxiety Disorder simultaneously. Himle states,

There’s increasing interest in treating both disorders at the same time. Cognitive Behavioral Therapy is particularly attractive because it has applications to both.

But sometimes the depression is so incapacitating that it has to be overcome first. For example, depression often interferes with exposure therapy for Anxiety, in which people gradually confront situations they avoid because they give rise to overwhelming fear. Himle notes:

Exposure therapy requires substantial effort. That’s effort that depressed people often do not have available to them.

Antidepressants can make a difference with both Anxiety Disorders and depression. Many SSRIs are approved for use in Anxiety Disorders and are the first line of drug therapy. But which drug works best for whom can not be predicted in advance; it may take some trial and error.

Ross finds CBT 80-90 percent successful in getting people functioning well, “provided it’s done correctly.” Not all psychotherapy is CBT, which has a very specific set of procedures, nor is every mental health professional trained in CBT. “Patients have to make sure that is what they are really getting.”

Treatment averages 12 to 15 weeks, and patients can expect to see significant improvement by six weeks. Ross says,

CBT doesn’t involve years and years of talk therapy. There’s homework, practice and development of lifestyle changes. Once patients learn how to identify the trigger thoughts or feelings, or events or people, they need to keep doing that. CBT gives people the tools they need.”

Medication and CBT are equally effective in reducing Anxiety Disorders and depression. But CBT is better at preventing relapse, and it creates greater patient satisfaction. “It’s more empowering,” says Yapko. “Patients like feeling responsible for their own success.” Further, new data suggests that the active coping CBT encourages creates new brain circuits that circumvent the dysfunctional response pathways.

In Summary

DSM first separated Anxiety Disorder and depression

The strong separation of Anxiety Disorders and depression into two disorders was introduced the third (1980) and fourth (1994) editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM) of the American Psychiatric Association. 

The DSM is not only used for diagnoses of mental illnesses worldwide, it shapes the mindset of mental health professionals formulating treatments for Anxiety Disorder and depression. With the increasing realization that Anxiety Disorders and depression are closely related, better psychotherapy strategies are being developed to deal with both disorders simultaneously. With all the research being done on the interconnectedness of Anxiety Disorders and depression, it will be interesting to see what how these disorders are handled in the new edition of the DSM, due in 2012. It may very well be that the diagnoses of two decades will be set on their ears by this new information.

In a recent article published in the British Medical Journal, physicians Edward Shorter of Canada and Peter Tyrer of England contend that this separation of Anxiety Disorder and depression, along with several different varieties of Anxiety, is a “wrong classification” that has led the pharmaceutical industry down a “blind alley.” It is also “one reason for the big slowdown in drug discovery in psychiatric drugs,” they say, adding that it is difficult to create effective drugs for marketing-driven disease “niches.”

What do you think?

It has been my experience that Anxiety Disorders and depression went hand in hand. True to Himle’s statement, I had been diagnosed first with depression, then bipolar disorder, before I began having severe problems with Anxiety Disorders in my 50’s. Looking back, I can see the roots of the Anxiety Disorders growing decades before they were diagnosed. I have to wonder how different my life would have been had I had the advantage of modern treatment early on.

  • Have you had experience with an Anxiety Disorder and depression at the same time?
  • If you have had CBT therapy, do you agree with the claim for 80-90 percent effectiveness?
  • Do you think there are other mental illness diagnoses that are artificially separated?

As always, your comments are welcome!

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Resources used in this post:

Hettema, John M. (2008). What is the genetic relationship between anxiety and depression? Retrieved June 25, 2008 from American Journal of Medical Genetics Web site:

Marano, Hara Estroff. (2007, September 11). Anxiety and Depression. Retrieved June 27, 2008 from Psych Central Web site:

Psychology Today. (2007). Anxiety and Depression Together. Retrieved September 23, 2008 from MedicineNet Web site:

Further reading:

Anxiety Disorders Association of America. Anxiety and Depression: What to Do When You Have Both

Walden Behavioral Care. Anxiety Depression

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12 comments… add one
samantha September 25, 2008, 2:04 am

“Great post. Here’s a website that can help you overcome
anxiety disorder without much hassle. You might want to give it a try at

amber January 26, 2009, 8:16 pm

what about all the side affects from the drugs used to treat anxiety and depression? isn’t there something safer?

MarkSpizer May 3, 2010, 9:25 am

great post as usual!

pat May 30, 2010, 12:43 pm

Very informative post. I have suffered from depression and anxiety since I was a child, with only depression being addressed. The anxiety was still a constant even while on medication except for the short time I was on Zoloft, which was the first time in my life I had a sense of well being. Unfortunately, it was short lived as the side effects interfered too much with the quality of my life.

Fast forward to the present, at age 60, and my most recent consultation with a psychiatrist whom confirmed my thoughts on anxiety being the base issue. After being given a huge amount of information on the pros and cons of pharmaceuticals vs natural supplements, I did learn that Sam E is the only non-toxic alternative supplement that can be taken. He said it would take 1-2 weeks to see improvement. I am at 1000 mg/day now and with a prescribed goal of 1200-1800 mg/day, depending on my response. Just finished a week and I’m feeling joy w/no side effects. I see a future. More importantly, I feel perfectly fine to leave my house now, am actually thinking and looking forward to finding a job, and don’t dread being around people (which was sometimes excruciating). In only a week this change has occurred and I feel as though I have been the gift of life. I’m curious to see when I’ve taken it for 2 full weeks. This is very exciting for me.

However, he did say it might not work and doesn’t work for everyone. Please check with you healthcare professional as everyone is unique and has their own unique life expriences that need to be evaluated.

John March 5, 2011, 3:42 pm

Excellent article providing a meaningful perspective towards the foundation of this issue affecting millions of people. Unfortunately, it’s really much more complex and it’s also deeply personal in terms of being unique to each individual. From how different meds work for different people, to different people are able to effectively employ different CBT resources, as well as the entire aspect of support being a variable, but so important during recovery.

I’m 41, I’ve had 3 major episodes of event-driven depressions towards near-suicides. I have suffered from some anxiety during these periods, specifically Trichotillomania (on rare occasions, quite severely). I am also a severe migraine sufferor. I’ve had a few meds prescribed in my adult life – initially Zoloft (horrible side effects). Ultimately, for me, the elimination of Lorazepam (a Benzo – Adavan) was a choice made, despite no past addictions, and just Cymbalta and Buproprion (Welbutrin) has been successful in addressing the biology side of the triangle.

I completed 9 days of in-patient to address the stress management and support management of the other 2 sides of the triangle – so to speak.

This is my point from my opening sentence. Depression and coping goes far beyond even the determination of whether you suffer from genetically driven or event driving depression – in the end, we all have those 3 sides of the triangle: biology, stress and support – that must be managed EVERY DAY.

Joe April 9, 2011, 3:01 pm

I so agree that one comes before another. In my case the anx came first, had it for almost 25-30 years before depression hit. Went on Effexor
to help but to be honest it eventually relieved the depression but it didn’t help the anx. much.
I’ve done CBT which can be helpful and use Ativan when needed to take the edge off. I’m now on 150mg of Effexor and want to get off. Then try a more natural method (5-HTP, Same-e, St. Johns, etc…) Then Eating well, fish oil, vit B, exercise, yoga, etc…
Any advice would be appreciated.

Sexperts May 23, 2011, 12:24 pm

Great article, these are definitely something I struggle with and I agree they are related. My psychiatrist also said they are two sides of the same coin.

Paul July 10, 2015, 6:54 am

I have DDNOS which is an anxiety based condition. I feel anxiety but I suspect it is not due to the condition, rather because of the life situation the condition has put me in. It is very difficult to judge whether I am right or not. I strongly suspect this after 13 years of having the condition. I was told today by a GP that DDNOS and depression are two sides of the same coin. I could not disagree more in terms of dealing with each condition. I had depression when I was young and experience of the two things are miles apart. My emotions are very level with DDNOS. I very rarely feel sadness at all.

Ravindra Negi February 26, 2019, 11:40 am

People worry. They don’t know what to do. This leads to anxiety. They can’t manage it. They try to avoid thoughts but can’t. They feel helpless. That is depression.

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